SEREVENT DISKUS contains salmeterol xinafoate. Many drugs besides salmeterol may affect the heart rhythm QT prolongation including amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics such as erythromycin among others. Therefore, before using salmeterol, report all medications you are currently using to your doctor or pharmacist. Appropriate use: Do not exceed recommended dose; serious adverse events, including fatalities, have been associated with excessive use of inhaled sympathomimetics.
Asthma: Appropriate use: Do not use for acute bronchospasm. Short-acting beta 2-agonist eg, albuterol should be used for acute symptoms and symptoms occurring between treatments. Do not initiate in patients with significantly worsening or acutely deteriorating asthma; reports of severe sometimes fatal respiratory events have been reported when salmeterol has been initiated in this situation. Corticosteroids should not be stopped or reduced when salmeterol is initiated. During initiation, watch for signs of worsening asthma. Idelalisib: May increase the serum concentration of CYP3A4 Substrates. Contents Under Pressure: Do not puncture.
Salmeteroli xinafoas PH: Ph. Eur. What should I discuss with my healthcare provider before using Advair Diskus fluticasone and salmeterol? Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.
Fluticasone and salmeterol is not a rescue medicine. It will not work fast enough to treat an asthma or bronchospasm attack. Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day. Iobenguane I 123: Sympathomimetics may diminish the therapeutic effect of Iobenguane I 123. In rats, salmeterol xinafoate is excreted in the milk.
AIRDUO RESPICLICK has not been evaluated. AUC, and no effect on urinary excretion of cortisol. How should I use Advair Diskus fluticasone and salmeterol? Tedizolid: May enhance the hypertensive effect of Sympathomimetics. Tedizolid may enhance the tachycardic effect of Sympathomimetics. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Talk to your doctor about using this medication safely. Your doctor will need to check your lung function on a regular basis. Once your asthma is under control, your doctor may want you to stop using this medicine. Instruct patients not to use other LABA. Read the Patient Information Leaflet provided by your before you start using this and each time you get a refill. This medication is used with a special machine called a that changes the solution to a fine mist that you inhale. Learn and follow all instructions for the use of this medication and the nebulizer. Children may need help from an adult to use this medication properly. If you have any questions, ask your doctor, pharmacist, or respiratory therapist. If you are using salmeterol to prevent breathing problems caused by exercise, use it at least 30 minutes before you start to exercise. Do not use another dose for at least 12 hours. If you already use salmeterol twice daily on a regular basis, do NOT take an extra dose before you exercise. Diabetes patients - Salmeterol may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. Older adults may be more sensitive to the side effects of this drug, especially QT prolongation see above. If you also use an oral steroid medication, you should not stop using it suddenly. Follow your doctor's instructions about tapering your dose. Carry an identification card or wear a medical alert ID to let others know that you may need an oral steroid in an emergency. Uses: Treatment of asthma in patients not adequately controlled on a long term asthma control medication such as an inhaled corticosteroid, or whose disease severity clearly warrants initiation of treatment with both an inhaled corticosteroid and a LABA What other drugs will affect fluticasone and salmeterol? Seek medical attention if you think your medications are not working as well. It is not known whether this medicine passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Aerosol, increase the risk of asthma-related death. Long-acting beta 2-agonists LABAs increase the risk of asthma-related deaths. Salmeterol should only be used in asthma patients as adjuvant therapy in patients who are currently receiving but are not adequately controlled on a long-term asthma control medication ie, an inhaled corticosteroid. Monotherapy with an LABA is contraindicated in the treatment of asthma. In a large, randomized, placebo-controlled US clinical trial SMART 2006 salmeterol was associated with an increase in asthma-related deaths when added to usual asthma therapy; risk is considered a class effect among all LABAs. Patients who are receiving SEREVENT DISKUS twice daily should not use additional SEREVENT for prevention of EIB. The median tmax was 5 minutes. Check your pressure regularly and tell your doctor if the results are high. AIRDUO RESPICLICK at recommended doses. Store vials in the foil pouch at room temperature away from light and heat. not store in the bathroom. After the foil pouch is opened, use the vials within 2 weeks. Once vials are removed from the foil pouch, use right away, or protect from light and use within 1 week. Keep all away from children and pets. Learn which of your inhalers you should use every day controller drugs and which you should use if your breathing suddenly worsens quick-relief drugs. Ask your doctor ahead of time what you should do if you have new or worsening cough or shortness of breath, wheezing, increased sputum, worsening peak flow meter readings, waking up at night with trouble breathing, if you use your quick-relief inhaler more often more than 2 days a week or if your quick-relief inhaler does not seem to be working well. Learn when you can treat sudden breathing problems by yourself and when you must get medical help right away. Do not use salmeterol inhalation to treat an asthma attack that has already begun. It will not work fast enough. Use only a fast-acting inhalation medication. Most patients are able to taste or feel a dose delivered from SEREVENT DISKUS. LABA such as formoterol Foradil or salmeterol Serevent. These medications should not be used with fluticasone and salmeterol inhalation. Your doctor will tell you which medication you should use and which medication you should stop using. Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose. What happens if I overdose? DISKUS should not use additional LABA for any reason. Each ampule of is for one-time use. Inspect each ampule before use. Normal solution is slightly yellow and may darken with age. Discard the ampule if the solution is cloudy or has particles in it, or if it has expired or has been stored at room temperature for longer than 28 days. Use all of the contents of the ampule for each dose. not mix tobramycin with any other medicines in the nebulizer. ADVAIR HFA, should be monitored.
Do not use this drug for patients whose asthma is adequately controlled on low or medium dose inhaled corticosteroids. Store the inhaler with the mouthpiece down. Post-hoc subpopulation analyses were performed. In a large clinical study, more patients with asthma who used salmeterol experienced severe episodes of asthma that had to be treated in a hospital or caused death than patients with asthma who did not use salmeterol. If you have asthma, use of salmeterol may increase the risk that you will develop serious or fatal asthma problems. There is not enough information available to tell whether inhaling fluticasone with salmeterol increases, decreases, or does not change this risk. Aprepitant: May increase the serum concentration of CYP3A4 Substrates. What are the possible side effects of salmeterol inhalation Serevent Diskus? Read the Patient Information Leaflet available from your before you start using this and each time you get a refill. This product is used with a special machine called a that changes the solution to a fine mist that you breathe in. Consult your doctor, pharmacist, or respiratory therapist on how to inhale this medication properly with this equipment. If a child is using this equipment, a parent or other responsible adult should supervise the child. ADVAIR HFA may harm your unborn baby. The relevance of these findings to human use is unknown. QT interval; ST segment depression. Direct stimulation of cardiac tissues is mediated by beta-1 receptors and thus less likely to occur with beta-2-selective agents such as albuterol. However, beta-2-selectivity is not absolute and can be lost with larger doses. High dosages of these agents have been associated with precipitation or aggravation of angina, myocardial ischemia, and cardiac arrhythmias. SEREVENT DISKUS should not be used with a spacer device. Never attempt to take the DISKUS apart. C with the mouthpiece down. DISKUS. Do not breathe in through your nose. SEREVENT Inhalation Aerosol for the prevention of EIB.
Ask your health care provider any questions you may have about how to use salmeterol. It is not known if this drug passes into breast milk. Consult your doctor before breast-feeding. Contact your doctor or seek medical care right away if you have breathing problems that worsen quickly, or if you use your rescue inhaler and do not get relief. ADVAIR HFA delivered with a spacer or ADVAIR DISKUS. Breathe out slowly as long as you can. SEREVENT DISKUS with non-potassium-sparing diuretics. CNS stimulation; serum glucose, serum potassium. Monitor for increased use of short-acting beta 2-agonist inhalers; may be marker of a deteriorating asthma condition. Check with your child's doctor to see if this product is the right product for your child. The clinical relevance of these growth data is not certain. Use tobramycin as directed by your doctor. Check the label on the medicine for exact dosing instructions. Do not stop taking any medications without consulting your healthcare provider. Stiripentol: May increase the serum concentration of CYP3A4 Substrates. Management: Use of stiripentol with CYP3A4 substrates that are considered to have a narrow therapeutic index should be avoided due to the increased risk for adverse effects and toxicity. Any CYP3A4 substrate used with stiripentol requires closer monitoring. Teva Pharmaceutical Industries Ltd. NYSE and TASE: TEVA is a leading global pharmaceutical company that delivers high-quality, patient-centric healthcare solutions used by millions of patients every day. AirDuo RespiClick is a fixed dose combination product containing the same active ingredients as Advair. AirDuo RespiClick is a corticosteroid and a long-acting beta 2-adrenergic agonist LABA indicated for the treatment of asthma in patients aged 12 years and older.
ADVAIR HFA at the same time each day, about 12 hours apart. If this medication stops working well, or you need to use your quick-relief inhaler more often than usual 4 or more puffs daily or use of more than 1 inhaler every 8 weeks seek immediate medical attention. It may be a sign of worsening asthma, which is a serious condition. ADVAIR HFA on preterm labor or labor at term. Salmeterol will not stop an asthma attack or other sudden, severe breathing problems once they have already started. Be sure to carry a rescue inhaler eg, albuterol with you at all times to treat any breathing problems that may occur between doses of salmeterol eg, severe or sudden onset of wheezing or shortness of breath. If you have any questions about which medicines stop asthma attacks or other sudden, severe breathing problems, check with your doctor or pharmacist. The initiation of ADVAIR HFA in this setting is not appropriate. Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal. AIRDUO RESPICLICK than with placebo. The metal canister holds the medicine. Exercise-induced bronchospasm: Prevention of exercise-induced bronchospasm EIB in patients 4 years and older monotherapy may be indicated in patients without persistent asthma. Available data from controlled clinical trials suggest that long-acting beta- 2 adrenergic agonists increase the risk of asthma-related hospitalization in pediatric and adolescent patients. For pediatric and adolescent patients with asthma who require addition of a long-acting beta- 2 adrenergic agonist to an inhaled corticosteroid, a fixed-dose combination product containing both an inhaled corticosteroid and a long-acting beta- 2 adrenergic agonist should ordinarily be used to ensure adherence with both drugs. In cases where use of a separate long-term asthma control medication eg, inhaled corticosteroid and a long-acting beta- 2 adrenergic agonist is clinically indicated, appropriate steps must be taken to ensure adherence with both treatment components. If adherence cannot be ensured, a fixed-dose combination product containing both an inhaled corticosteroid and a long-acting beta- 2 adrenergic agonist is recommended. It works in the airways by opening breathing passages and relaxing muscles. Controlling symptoms of breathing problems can decrease time lost from work or school. Non-Site Specific: Fever, pallor. DISKUS. Similar definitive studies have not been performed with ADVAIR HFA. Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. FEV 1 on apparent clearance and apparent volume of distribution.
MDPI expressed as metered dose. Use in Specific Populations: Since both fluticasone propionate and salmeterol are predominantly cleared by hepatic metabolism, impairment of liver function may lead to accumulation of fluticasone propionate and salmeterol in plasma. Triangle Park, NC 27709. AirDuo RespiClick is indicated for the treatment of asthma in patients aged 12 years and older. If any of these effects persist or worsen, tell your doctor promptly. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose and resume your usual dosing schedule. Use salmeterol inhalation regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely. Always activate and use this device in a level, horizontal position. Do NOT try to use a spacer device with salmeterol. RESPICLICK or from the underlying maternal condition. AIRDUO RESPICLICK with non-potassium-sparing diuretics. Phase 2 and 3 studies. Beta-Blockers Nonselective: May diminish the bronchodilatory effect of Beta2-Agonists. Tobramycin only works against bacteria; it does not treat viral infections eg, the common cold.
Store at room temperature between 59-86 degrees F 15-30 degrees C away from light and moisture. not store in the bathroom. Keep all medicines away from children and pets. The strap on the cap will stay attached to the actuator. AIRDUO RESPICLICK, increase the risk of -related death. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, tongue, or throat; unusual hoarseness; chest pain; choking; fast or irregular heartbeat; fever; new or worsening asthma or COPD symptoms eg, coughing, increased chest tightness, shortness of breath, wheezing; overexcitement; severe or persistent headache, dizziness, or nervousness; severe or persistent muscle pain or cramps; symptoms of high blood sugar eg, increased thirst, urination, or hunger; unusual weakness or drowsiness; confusion; tremor. Patient may experience rhinitis, pharyngitis, or rhinorrhea. Have patient report immediately to prescriber signs of high blood sugar confusion, fatigue, increased thirst, increased hunger, polyuria, flushing, fast breathing, or breath that smells like fruit signs of low potassium muscle pain or weakness, muscle cramps, or an abnormal heartbeat angina, tachycardia, abnormal heartbeat, severe anxiety, severe headache, seizures, passing out, severe nausea, vomiting, severe loss of strength and energy, insomnia, severe dizziness, tremors, difficulty breathing, wheezing, or severe cough HCAHPS. Tell your doctor if your symptoms do not improve or if they worsen. Ecchymoses, photodermatitis. Vascular Disorders: Pallor. Tobramycin may cause fetal harm if used during pregnancy. This medication may slow down a child's growth if used for a long time, but poorly controlled can also slow down growth. The effect on final adult height is unknown. See the doctor regularly so your can be checked.
Store at room temperature away from light, heat, and moisture. not store in the bathroom. Store the with the mouthpiece down. Do not puncture the canister or use near an open flame. Keep all medicines away from children and pets. AIRDUO RESPICLICK may need to be interrupted. Be sure to mention any of the following: antifungals such as fluconazole Diflucan itraconazole Sporanox and ketoconazole Nizoral; beta-blockers such as atenolol Tenormin labetalol Normodyne metoprolol Lopressor, Toprol XL nadolol Corgard and propranolol Inderal; cimetidine Tagamet; clarithromycin Biaxin; cyclosporine Neoral, Sandimmune; danazol Danocrine; delavirdine Rescriptor; diltiazem Cardizem, Dilacor, Tiazac; diuretics 'water pills'; fluoxetine Prozac, Sarafem; fluvoxamine Luvox; HIV protease inhibitors such as atazanavir Reyataz indinavir Crixivan nelfinavir Viracept ritonavir Norvir and saquinavir Invirase; isoniazid INH, Nydrazid; other medications for asthma or COPD; medications for seizures; metronidazole Flagyl; nefazodone; oral contraceptives birth control pills; telithromycin Ketek; troleandomycin TAO; verapamil Calan, Covera, Isoptin, Verelan; and zafirlukast Accolate. Also tell your doctor and pharmacist if you are taking the following medications or have stopped taking them during the past 2 weeks: antidepressants such as amitriptyline Elavil amoxapine Asendin clomipramine Anafranil desipramine Norpramin doxepin Adapin, Sinequan imipramine Tofranil nortriptyline Aventyl, Pamelor protriptyline Vivactil and trimipramine Surmontil; and monoamine oxidase MAO inhibitors, including isocarboxazid Marplan phenelzine Nardil selegiline Eldepryl and tranylcypromine Parnate. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Excessive Use and Use with Other Long acting Beta 2-Agonists: AirDuo RespiClick should not be used more often than recommended, at higher doses than recommended, or in conjunction with other medicines containing LABA, as an overdose may result. Clinically significant cardiovascular effects and fatalities have been reported in association with excessive use of inhaled sympathomimetic drugs. Controlling these symptoms can decrease time lost from work or school. Metaproterenol is a beta-2 receptor agonist that works by opening breathing passages to make breathing easier. This drug is also known as orciprenaline in other countries. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. If your symptoms do not improve or if they become worse, check with your doctor. These medications may cause some risk when taken together. NHLBI 2007. Assess patients at regular intervals once asthma control is maintained on combination therapy to determine if step-down therapy is appropriate and the LABA can be discontinued without loss of asthma control and the patient can be maintained on an inhaled corticosteroid. LABAs are not appropriate in patients whose asthma is adequately controlled on low- or medium-dose inhaled corticosteroids. Only the inhalation powder fluticasone 250 mcg-salmeterol 50 mcg is indicated for the treatment of COPD. This medication may mask signs of infection. It can make you more likely to get infections or may worsen any current infections. Therefore, well to prevent the spread of infection. RESPICLICK dose as assessed by FEV 1 following 12 weeks of therapy. Rinse your mouth with water, but do not swallow.
Use tobramycin with caution in the ELDERLY; they may be more sensitive to its effects, especially kidney or hearing problems. Do not take the inhaler apart. Talk with your doctor or pharmacist about all of your asthma medicines and how to use them. Your doctor may make changes to your asthma-control medicines once your asthma is well controlled. Instruct patients not to use other LABA for asthma. Store vials in the foil pouch at room temperature away from light and heat. not store in the bathroom. After the foil pouch is opened, use the right away. Throw away any vials if the solution is discolored. Keep all away from children and pets. It is unknown if this medication passes into milk. Consult your doctor before -feeding.
ADVAIR HFA regularly for 1 week. Patients should consider regular eye exam. Adolescents: Refer to adult dosing. Do not use fluticasone and salmeterol during an attack of asthma or COPD. Your doctor will prescribe a short-acting inhaler to use during attacks. Salmeterol is a substrate of CYP3A4. PREGNANCY and BREAST-FEEDING: Tobramycin has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using tobramycin while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking tobramycin. Hold the device in a level, flat position with the mouthpiece toward you. Use your thumb to slide the lever away from you as far as it will go. You should hear a click. The device is now ready for use. Do not throw into fire or an incinerator. It may take 1 week or longer before you get the full benefit of this drug. Tell your doctor if your symptoms do not improve or if they worsen. Note: Do not use for the relief of acute bronchospasm. While using this medicine, your vision and your bone mineral density may need to be checked often.
Do not give this medication to a child younger than 4 years old. Take this by with or without food, usually 3-4 times daily or as directed by your doctor. Dosage is based on your medical condition and response to therapy. This should not be used if you have certain medical conditions. Patient information: Patients must be instructed to use inhaled short-acting beta 2-agonists eg, albuterol for acute asthmatic or COPD symptoms and to seek medical attention in cases where acute symptoms are not relieved or a previous level of response is diminished. The need to increase frequency of use of inhaled short-acting beta 2-agonist may indicate deterioration of asthma, and medical evaluation must not be delayed. Salmeterol should not be used more than twice daily; do not use with other long-acting beta 2-agonists. Store ampules in the refrigerator between 36-46 degrees F 2-8 degrees C away from light. Ampules may also be stored at room temperature up to 77 degrees F 25 degrees C for up to 28 days. Keep all medicines away from children and pets. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. AIRDUO RESPICLICK in children or geriatric patients. For oral inhalation route only. Before inhaling the dose, breath out fully; do not exhale into the Diskus device; activate and use only in a level, horizontal position. Inhale quickly and deeply through the Diskus; hold breath for about 10 seconds or for as long as comfortable and exhale slowly. Do not use with a spacer device or wash mouthpiece; Diskus should be kept dry. Discard device 6 weeks after removal from foil pouch or when the dose counter reads "0" whichever comes first. AIRDUO RESPICLICK more than 2 times every 24 hours.
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Talk to your doctor about the risks of using this medication. AIRDUO RESPICLICK inhaler was 108. Keep out of reach of children.
Safely throw away the pouch. RESPICLICK in healthy subjects. Diarrhea; headache; nausea; pain, swelling, or redness at the injection site; vomiting.
Less than 4 years: Not recommended. Learn which of your inhalers you should use every day controller drugs and which you should use if your breathing suddenly worsens quick-relief drugs. Some of these products contain sulfites. Sulfites may cause an allergic reaction in some patients eg, asthma patients. Additional doses should not be taken for 12 hours.
Because the can worsen breathing problems, ask your doctor or if you should have a every year. COPD is increased by LABA. Thiazide and Thiazide-Like Diuretics: Beta2-Agonists may enhance the hypokalemic effect of Thiazide and Thiazide-Like Diuretics. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. There may be new information.